On October 21, 2008, the recording group released their fifth studio album, The Sound.[5][6] The lead single “Get Up” was released digitally via iTunes on July 15, 2008. The Sound saw Mary Mary achieve even greater success in the mainstream market; the album sold over 37,000 copies in its first week, and was their best charting album to date, debuting No. 7 on the Billboard 200, No. 2 on the US R&B chart, and topping the gospel and CCM charts. The album held the No. 1 position on the Billboard Gospel Album chart for over six months since its release. Warryn Campbell again returned to produce the album and saw collaborations with Kierra Sheard, David Banner, Marvin Winans, Daryl Coley, Andrae Crouch, Rance Allen, Dorinda Clark Cole, Joe Ligon, Walter Hawkins, Tramaine Hawkins, and Karen Clark Sheard. In Spring 2009 “God In Me” began achieving crossover success (as Shackles had nine years earlier), reaching No. 5 on the Hot R&B/Hip-Hop Songs, and No. 1 on the Hot Dance Club Play.
The duo (along with Warryn Campbell) was nominated as songwriters at the 52nd Grammy Awards in the Best Gospel Song category for “God in Me” while the Israel Houghton song they were featured on “Every Prayer” was also nominated. They went on to win the award. The album also won Mary Mary four Stellar Awards on January 16, 2010.